| Noun | 1. | Santiago - city in the northern Dominican Republic Synonyms: Santiago de los Caballeros |
| 2. | Santiago - port city in southeastern Chile; industrial center Synonyms: Santiago de Cuba | |
| 3. | Santiago - the capital and largest city of Chile; located in central Chile; one of the largest cities in South America | |
| 4. | Santiago - a naval battle in the Spanish-American War (1898); the United States fleet bottled up the Spanish ships in the harbor of Santiago de Cuba and destroyed them when they tried to escape Synonyms: Santiago de Cuba |